Bioactive Small Molecules
![Chemscene ChemScene | 5-Azaspiro[2.5]octane-6,8-dione | 100MG | CS-0163566 | 0.98 | 845267-72-3| MFCD19218035 | 139.15](https://assets.fishersci.com/TFS-Assets/CCG/product-images/CS-0163566.JPG-250.jpg)
Chemscene ChemScene | 5-Azaspiro[2.5]octane-6,8-dione | 100MG | CS-0163566 | 0.98 | 845267-72-3| MFCD19218035 | 139.15
ChemScene | 5-Azaspiro[2.5]octane-6,8-dione | 100MG | CS-0163566 | 0.98 | 845267-72-3| MFCD19218035 | 139.15
Medchemexpress LLC Shogaol | 555-66-8 | 99.84% | 276.37 | 25 MG
Shogaol (-Shogaol) is an active compound isolated from Ginger (Zingiber officinale Rosc) with diverse biological activities, including anticancer, anti-inflammation, and anti-oxidation. It is for research use only.
- Active compound isolated from ginger
- Exhibits anticancer activity
- Exhibits anti-inflammatory activity
- Exhibits anti-oxidation activity
- Cytotoxic in various cell lines
- Stimulates phosphorylations of mitogen-activated protein kinases (MAPKs)
- Decreases diethylnitrosamine (DEN)-mediated elevations of serum transaminase
- Up-regulates antioxidant defense systems
- Restores DEN-reduced activity of hepatic antioxidant enzymes
Cayman Chemical ANTIBODY Carbazern 5mg
An inhibitor of PDE2 and PDE3; inhibits cAMP hydrolysis (IC50 = 4.1 µM in rabbit heart ventricles) selectively over cGMP hydrolysis (IC50 = 171 µM); induces positive inotropic (EC50 = 100 µM) and negative chronotropic effects in isolated rabbit papillary muscle and right atria, respectively; a substrate for AOX1
Cayman Chemical ANTIBODY RN-18 25mg
An HIV-1 Vif inhibitor; inhibits Vif-mediated degradation of the DNA editing enzyme APOBEC3G (IC50s = 10-30 µM); inhibits HIV-1 viral replication (IC50s = 4.5 and 10 µM for nonpermissive CEM and H9 cells, respectively, and >100 µM for permissive cells)
Medchemexpress LLC 3'-O-(2-Methoxyethyl)guanosine | 256224-03-0 | C13H19N5O6 | 1 ML
3'-O-(2-Methoxyethyl)guanosine is a guanosine analogue exhibiting immunostimulatory activity. It induces type I interferons, leading to antiviral effects. Its functional activity is dependent on the activation of Toll-like receptor 7 (TLR7).
- Immunostimulatory activity
- Induces type I interferons for antiviral effects
- Activates Toll-like receptor 7 (TLR7)
- Molecular weight: 341.32
- Purity: 98.90%
- Appearance: Solid
- Color: White to off-white
- Stable for long-term storage as powder at -20°C (3 years) or 4°C (2 years)
- Stable for short-term storage in solvent at -80°C (6 months) or -20°C (1 month)
Cayman Chemical ANTIBODY 1-EBIO 100mg
An activator of Ca2+-sensitive K+ channels (EC50 = 490 µM in T84 human carcinoma cells); also activates the human intermediate conductance Ca2+-activated K+ channel (EC50 = 74 µM)
Cayman Chemical ANTIBODY SenxIn B 1mg
An inhibitor of Cdk8 and Cdk19; inhibits Cdk8 (IC50s = 24-50 nM, depending on assay); selectively inhibits Cdk19 and Cdk8 by 98.6 and 97.8%, respectively, in a panel of >450 kinases at 2 μM but does inhibit MAP4K2 and YSK4 by 69 and 59%, respectively; inhibits cell growth in MCF-7, BT474, and T47D-ER/Luc breast cancer cells in estrogen-containing media at 1.25-5 μM; reduces tumor growth in an MCF-7 mouse xenograft model at 100 mg/kg twice per day; inhibits RANKL-induced differentiation of murine BMDMs into osteoclasts at 1 and 1.5 μM; increases the bone volume fraction and bone mineral density in injured tibiae in a rat model of cancellous bone injury and regeneration when administered locally at 1 μg
Medchemexpress LLC FKB04 | 99.98% | 363.20 | 25 MG
FKB04 is a telomeric repeat binding factor 2 (TRF2) inhibitor that disrupts the telomere maintenance mechanism in liver cancer cells. This leads to T-loop defects, telomere shortening, and cellular senescence, thereby exerting antitumor activity. It can also inhibit tumor growth in a human liver cancer xenograft mouse model. This compound is intended for liver cancer research.
- Disrupts telomere maintenance mechanism in liver cancer cells
- Leads to T-loop defects, telomere shortening, and cellular senescence
- Exerts antitumor activity
- Inhibits tumor growth in a human liver cancer xenograft mouse model
- Used in liver cancer research
![Medchemexpress LLC (2R)-1,1,1-trifluoro-2-[4-[(2S)-2-[[(3S)-3-methylmorpholin-4-yl]methyl]-4-thiophen-2-ylsulfonylpip... | 1361217-07-3 | >98.0% | 533.63 g·mol⁻¹ | C23H30F3N3O4S2 | 1MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000234926.png-250.jpg)
Medchemexpress LLC (2R)-1,1,1-trifluoro-2-[4-[(2S)-2-[[(3S)-3-methylmorpholin-4-yl]methyl]-4-thiophen-2-ylsulfonylpip... | 1361217-07-3 | >98.0% | 533.63 g·mol⁻¹ | C23H30F3N3O4S2 | 1MG
AMG-1694 is a small-molecule glucokinase-glucokinase regulatory protein (GK-GKRP) disruptor used as a biochemical research tool to promote dissociation of the GK-GKRP complex, increase glucokinase activity, and modulate glucose metabolism. It has potent biochemical activity (IC50 ≈ 7 nM) and has shown blood-glucose-lowering effects in diabetic rodent models.
- Potent GK-GKRP disruption with low-nanomolar activity.
- Increases glucokinase enzymatic activity and promotes translocation.
- Demonstrated efficacy in rodent models for glycemic control.
- Suitable for biochemical and cellular assays involving glucose metabolism.
- Characterized chemical properties: molecular weight 533.63 g·mol⁻¹ and formula C23H30F3N3O4S2.
Cayman Chemical ANTIBODY 4u8C 25mg
An IRE1α inhibitor; inhibits IRE1α splicing of Xbp1 mRNA (IC50 = 6.8 µM); reduces Erdj4 gene expression downstream of IRE1α and Xbp1 (IC50 = 3.4 µM); does not block IRE1α autophosphorylation; reduces IL-4 production in CD4+ T cells; reduces LPS-stimulated increases in TNF-α and IL-6 mRNA expression and protein secretion
Medchemexpress LLC 2-chlorophenyl diphenylmethanol | 66774-02-5 | 99.6% | 5 G
(2-Chlorophenyl)diphenylmethanol (CAS 66774-02-5) is a triarylmethanol compound supplied as a reference standard for research and analytical applications. It has molecular formula C19H15ClO, molecular weight 294.77 g/mol, and reported purity of 99.56%. Typically provided as a 5 g solid for laboratory use.
- Used as a reference standard for analytical and biochemical assays.
- High reported purity suitable for method development and QC.
- Small pack size supports laboratory-scale experiments.
- Solid form simplifies handling and storage.
- Identified by CAS number for unambiguous compound reference.
AdipoGen S-Roscovitine
Chemical. CAS 186692-45-5. Formula C19H26N6O. MW 354.5. S-enantiomer of R-roscovitine Prod. No. MR-C0001. Potent selective cyclin-dependent kinase 1 CDK1 inhibitor. Potential neuroprotectant for stroke. Crosses the blood brain barrier. Inhibits CDK5, consequently blocking hypoxia-induced apoptosis in neurons. Potential anti-inflammatory compound. Potential antidiabetic compound.
Medchemexpress LLC AZD-9574-acid | 2923687-90-3 | 99.4% | 415.39 | 1 MG
AZD-9574-acid (70D) is a PPAR-1 inhibitor that can be utilized for the synthesis of PROTAC.
- PPAR-1 inhibitor
- Can be used for the synthesis of PROTAC